Therapeutic AreaFormulary ChoicesCost for 28
(unless otherwise stated)
Rationale for decision / comments
3.7 Mucolytics
375mg capsules: £11.21 (120)
125mg/5ml liquid: £5.08 (300ml)
250mg/5ml liquid: £8.39 (300ml)
750mg/10ml oral solution sachets £3.85 (15 x 10ml)
Do not routinely use to prevent exacerbations.
Carbocisteine can be considered in patients with COPD with copious of tenacious sputum. Trial carbocisteine 750mg tds for 4 weeks and stop if ineffective. If effective reduce to bd.

Dose: initially 2.25g daily in divided doses, then 1.5g daily in divided doses as condition improves.

Acetylcysteine is unlicensed in the UK and for specialist prescribing only. Red drug classification

Erdocysteine is non-formulary