Therapeutic AreaFormulary ChoicesCost for 28
(unless otherwise stated)
Rationale for decision / comments
13.4 Topical corticosteroids
Are licenced for application ONCE or TWICE daily only. Aim for a break of 4 weeks between courses of treatment with potent or very potent corticosteroids. Do not use very potent corticosteroids continuously at any site for longer than 4 weeks. Do not use potent corticosteroids continuously at any site for longer than 8 weeks.
Twice weekly maintenance therapy with a topical corticosteroid should be considered in patients with moderate to severe atopic eczema experiencing frequent relapses.

The Finger Tip Unit (FTU) is a useful means of calculating approximate quantities required, as follows (1 FTU = 0.5g)
Face and neck: 2.5 FTU , Trunk: 7 FTU (front) and 7 FTU (back), One arm: 3 FTU, One hand: 1 FTU, One leg: 6 FTU, One foot: 2 FTU
Total quantities of topical steroids required per week based on “bd” application for an adult:
Face and neck: 15-30g, Trunk: 100g, Both arms: 50g, both hands: 15-30g, Both legs: 100g, Groins and genitalia: 15-30g
General note: Avoid prescribing dermatologicals that need to be made extemporaneously owing to the excessive costs of ‘special’ items. This does not apply to ready made dilutions such as Betnovate RD®
Topical corticosteroids Most available as creams and ointments.
Patients with atopic eczema should be advised to apply topical corticosteroids once daily (SIGN CG125).
Twice weekly maintenance therapy should be considered in frequently relapsing moderate to severe atopic eczema (SIGN CG125).
NB Potency of a steroid is a product of the formulation as well as the corticosteroid
Caution: Hydrocortisone butyrate is a potent steroid (Locoid®)

Note: Hydrocortisone 2.5% is not cost-effective
Mildly potent
First-line
Hydrocortisone 1%
1st optionMildison® Lipocream
Hydrocortisone 1%
Cream: £1.71 (30g)Oily cream
2nd optionHydrocortisone 1%Cream: £1.04 (15g)
£2.08 (30g)
£3.47 (50g)
Ointment: £1.11 (15g)
£2.22 (30g)
£3.70 (50g)
Second lineHydrocortisone 0.5%Cream: £1.27 (15g)
£2.96 (30g)
Ointment: £4.90 (30g)
Mild with AntimicrobialsFucidin H®(Hydrocortisone 1% + Fusidic acid 2%) is non-formulary due to high levels of local resistance.

First line
1st optionCanesten HC®
(Hydrocortisone 1% + Clotrimazole 1%)
Cream: £2.42 (30g)
2nd optionDaktacort®
(Hydrocortisone 1% + Miconazole 2%)
Cream: £2.49 (30g)
Ointment: £2.50 (30g)
Second-lineTerra-cortril®
(Hydrocortisone 1% + Oxytetracycline hydrochloride 3%)
Ointment: £5.01 (30g)
Third line
Option 1Timodine® cream £3.37 (30g)Contains: nystatin 100,000iu/g, hydrocortisone 0.5%, benzalkonium chloride soln 0.2%, dimeticone 350 10%
Potential sensitisers: benzalkonium chloride

Option 2Nystatin 100,000 units/g/ chlorhexidine acetate 1%/HC 1% oint£5.29 (30g)
Generic version of Nystaform HC which is discontinued
Contains: nystatin 100,000iu/g, chlorhexidine 1%, hydrocortisone 0.5%
Potential sensitisers: chlorhexidine acetate
Option 3If topical triple combination (corticosteroid + antimicrobial + antifungal) is required, consideration can also be given to:
Dual formulation of corticosteroid + antimicrobial: Terra-cortril® - Hydrocortisone 1% + Oxytetracycline hydrochloride 3%; Ointment: £5.01 (30g) & Adding miconazole nitrate cream 2% (Daktarin® 2% Cream 30g; £1.82) NB - clotrimazole 1% cream, including Canesten® 1%, contains cetostearyl alcohol which is a potential sensitiser
Moderately potent
First-lineBetamethasone valerate 0.025%Audavate RD®
Cream: £2.52 (100g)
Ointment: £2.52 (100g)
Betnovate RD®
Cream: £3.15 (100g)
Ointment: £3.15 (100g)
Second line
1st option
Clobetasone butyrate 0.05%
Clobavate®
Ointment: £1.49 (30g)
£4.35 (100g)
Eumovate®
Cream: £1.86 (30g)
£5.44 (100g)
Ointment: £1.86 (30g)
£5.44 (100g)
2nd options
Modrasone®
(Alclometasone dipropionate 0.05%)
Cream: £2.68 (50g)
Haelan®
(Fludroxycortide 0.0125%)
Cream: £3.26 (60g)
Ointment: £3.26 (60g)
Moderate with antimicrobialsTrimovate has been relaunched as an unlicensed product from Feb 24th and is therefore non-formulary. There is no triple therapy alternative available
(clobetasone butyrate 0.05%, oxytetracycline 3%, nystatin 100 000 units/g)

Cream: £14.95 (30g) plus a £20 delivery chargeTrimovate Cream is a yellow water-miscible cream containing clobetasone butyrate 0.05% w/w, oxytetracycline 3.0% w/w as calcium oxytetracycline and nystatin 100,000 units per gram.
Moderate - compound preparations
First-line:Alphaderm®
(Hydrocortisone 1% & Urea 10%)®
Cream: £2.39 (30g)
£7.03 (100g)
Second-line:Calmurid HC®
(Hydrocortisone 1%, Urea 10% & Lactic Acid 5%)
Cream: £2.81(30g),
PotentPotent topical steroids should not be prescribed on repeat prescriptions.
The following preparations are deemed not cost-effective and are non-formulary:
- Beclometasone dipropionate 0.025% cream and ointment
- Bettamousse® (Betamethasone valerate 0.1%) foam scalp application
- Clobetasol 500microgram /Neomycin 5mg / Nystatin 100,000units/g
First-lineBetamethasone valerate 0.1%
(branded versions are cheaper than generics)
Audavate®
Ointment: £1.15 (30g)
£3.24 (100g)
Betnovate®
Cream: £1.43 (30g)
£4.05 (100g)
Ointment: £1.14 (30g)
£3.24 (100g)
Lotion: £4.58 (100ml)
Betacap®
Scalp Application:
£3.19 (100ml)
Second-line
1st option
Locoid® (Hydrocortisone butyrate 0.1%)Cream: £1.60 (30g)
£4.93 (100g)
Lipocream: £1.69 (30g)
£5.17 (100g)
Ointment: £1.60 (30g)
£4.93 (100g)
Scalp lotion: £6.83 (100ml)
2nd optionDiprosone® (Betamethasone Dipropionate 0.05%)Cream: £2.16 (30g)
£6.12 (100g)
Ointment: £2.16 (30g)
£6.12 (100g)
Scalp lotion: £2.73 (30ml)
£7.80 (100ml)
Potent with antimicrobials
First-line
1st option
Synalar C®
(Clioquinol 3% / Fluocinolone acetonide 0.025%)
Cream: £2.66 (15g)
Ointment: £2.66 (15g)
2nd optionSynalar N®
(Neomycin sulfate 0.5% / Fluocinolone acetonide 0.025%)
Cream: £4.36 (30g)
Ointment: £4.36 (30g)
Second-line
1st option
Lotriderm®
(Betamethasone Dipropionate 0.064%/ Clotrimazole 1.0%)
Cream: £6.34 (30g)
2nd optionAureocort®
(Chlortetracycline hydrochloride 3.09%/ triamcinolone acetonide 0.1%)
Ointment: £3.51 (15g)
Very potentVery potent topical steroids should not be prescribed on repeat prescriptions.
Clobetasol propionate 0.05%)ClobaDerm®
Cream: £2.15 (30g)
£6.32 (100g)
Ointment: £2.15 (30g)
£6.32 (100g)
Etrivex®
Shampoo: £10.29 (125ml)